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Inhibition of HIV-1 reverse transcription by triple-helix forming oligonucleotides with viral RNA.
Reverse transcription of retroviral RNA into double-stranded DNA is catalyzed by reverse transcriptase (RT). A highly conserved polypurine tract (PPT) on the viral RNA serves as primer for plus-strand DNA synthesis and is a possible target for triple-helix formation. Triple-helix formation during re...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1995
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306832/ https://ncbi.nlm.nih.gov/pubmed/7537875 |
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