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Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant to TRAIL. Bisphosphonates are very effective in the treatment of bone proble...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Moon, Myung-Hee, Jeong, Jae-Kyo, Seo, Jae-Suk, Seol, Jae-Won, Lee, You-Jin, Xue, Meilang, Jackson, Christopher J., Park, Sang-Youel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068296/
https://ncbi.nlm.nih.gov/pubmed/21297379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2011.43.3.016
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