CD45 Deficiency Drives Amyloid-β Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice

Converging lines of evidence indicate dysregulation of the key immunoregulatory molecule CD45 (also known as leukocyte common antigen) in Alzheimer's disease (AD). We report that transgenic mice overproducing amyloid-β peptide (Aβ) but deficient in CD45 (PSAPP/CD45(−/−) mice) faithfully recapit...

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Main Authors: Zhu, Yuyan, Hou, Huayan, Rezai-Zadeh, Kavon, Giunta, Brian, Ruscin, Amanda, Gemma, Carmelina, Jin, JingJi, Dragicevic, Natasa, Bradshaw, Patrick, Rasool, Suhail, Glabe, Charles G., Ehrhart, Jared, Bickford, Paula, Mori, Takashi, Obregon, Demian, Town, Terrence, Tan, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068193/
https://ncbi.nlm.nih.gov/pubmed/21273420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3268-10.2011
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