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CD45 Deficiency Drives Amyloid-β Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice

Converging lines of evidence indicate dysregulation of the key immunoregulatory molecule CD45 (also known as leukocyte common antigen) in Alzheimer's disease (AD). We report that transgenic mice overproducing amyloid-β peptide (Aβ) but deficient in CD45 (PSAPP/CD45(−/−) mice) faithfully recapit...

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Bibliografiske detaljer
Main Authors: Zhu, Yuyan, Hou, Huayan, Rezai-Zadeh, Kavon, Giunta, Brian, Ruscin, Amanda, Gemma, Carmelina, Jin, JingJi, Dragicevic, Natasa, Bradshaw, Patrick, Rasool, Suhail, Glabe, Charles G., Ehrhart, Jared, Bickford, Paula, Mori, Takashi, Obregon, Demian, Town, Terrence, Tan, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068193/
https://ncbi.nlm.nih.gov/pubmed/21273420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3268-10.2011
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