CD45 Deficiency Drives Amyloid-β Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice

Converging lines of evidence indicate dysregulation of the key immunoregulatory molecule CD45 (also known as leukocyte common antigen) in Alzheimer's disease (AD). We report that transgenic mice overproducing amyloid-β peptide (Aβ) but deficient in CD45 (PSAPP/CD45(−/−) mice) faithfully recapit...

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Detalhes bibliográficos
Main Authors: Zhu, Yuyan, Hou, Huayan, Rezai-Zadeh, Kavon, Giunta, Brian, Ruscin, Amanda, Gemma, Carmelina, Jin, JingJi, Dragicevic, Natasa, Bradshaw, Patrick, Rasool, Suhail, Glabe, Charles G., Ehrhart, Jared, Bickford, Paula, Mori, Takashi, Obregon, Demian, Town, Terrence, Tan, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068193/
https://ncbi.nlm.nih.gov/pubmed/21273420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3268-10.2011
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