CD45 Deficiency Drives Amyloid-β Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice

Converging lines of evidence indicate dysregulation of the key immunoregulatory molecule CD45 (also known as leukocyte common antigen) in Alzheimer's disease (AD). We report that transgenic mice overproducing amyloid-β peptide (Aβ) but deficient in CD45 (PSAPP/CD45(−/−) mice) faithfully recapit...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Zhu, Yuyan, Hou, Huayan, Rezai-Zadeh, Kavon, Giunta, Brian, Ruscin, Amanda, Gemma, Carmelina, Jin, JingJi, Dragicevic, Natasa, Bradshaw, Patrick, Rasool, Suhail, Glabe, Charles G., Ehrhart, Jared, Bickford, Paula, Mori, Takashi, Obregon, Demian, Town, Terrence, Tan, Jun
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Society for Neuroscience 2011
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Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068193/
https://ncbi.nlm.nih.gov/pubmed/21273420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3268-10.2011
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