Efficient Culture Adaptation of Hepatitis C Virus Recombinants with Genotype-Specific Core-NS2 by Using Previously Identified Mutations

Hepatitis C virus (HCV) is an important cause of chronic liver disease, and interferon-based therapy cures only 40 to 80% of patients, depending on HCV genotype. Research was accelerated by genotype 2a (strain JFH1) infectious cell culture systems. We previously developed viable JFH1-based recombina...

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Main Authors: Scheel, Troels K. H., Gottwein, Judith M., Carlsen, Thomas H. R., Li, Yi-Ping, Jensen, Tanja B., Spengler, Ulrich, Weis, Nina, Bukh, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067958/
https://ncbi.nlm.nih.gov/pubmed/21177811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01605-10
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