A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across Genotypes

The hepatitis C virus (HCV) genotype 2a isolate JFH1 represents the only cloned HCV wild-type sequence capable of efficient replication in cell culture as well as in vivo. Previous reports have pointed to NS5B, the viral RNA-dependent RNA polymerase (RdRp), as a major determinant for efficient repli...

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Detalhes bibliográficos
Main Authors: Schmitt, Melanie, Scrima, Nathalie, Radujkovic, Danijela, Caillet-Saguy, Célia, Simister, Philip C., Friebe, Peter, Wicht, Oliver, Klein, Rahel, Bartenschlager, Ralf, Lohmann, Volker, Bressanelli, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067924/
https://ncbi.nlm.nih.gov/pubmed/21209117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02177-10
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