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Cooperative Cleavage of the R Peptide in the Env Trimer of Moloney Murine Leukemia Virus Facilitates Its Maturation for Fusion Competence

The spike protein of murine leukemia virus, MLV, is made as a trimer of the Env precursor. This is primed for receptor-induced activation of its membrane fusion function first by cellular furin cleavage in the ectodomain and then by viral protease cleavage in the endodomain. The first cleavage separ...

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Detalhes bibliográficos
Main Authors: Löving, Robin, Kronqvist, Malin, Sjöberg, Mathilda, Garoff, Henrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067867/
https://ncbi.nlm.nih.gov/pubmed/21228228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02500-10
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