Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated Innate Immune Recognition

Fowlpox virus (FWPV) is a double-stranded DNA virus long used as a live-attenuated vaccine against poultry diseases, but more recent interest has focused on its use as a mammalian vaccine vector. Here, in a mouse model system using FWPV encoding the nominal target antigen chicken ovalbumin (OVA) (FW...

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Detalhes bibliográficos
Main Authors: Lousberg, Erin L., Diener, Kerrilyn R., Fraser, Cara K., Phipps, Simon, Foster, Paul S., Chen, Weisan, Uematsu, Satoshi, Akira, Shizuo, Robertson, Sarah A., Brown, Michael P., Hayball, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067835/
https://ncbi.nlm.nih.gov/pubmed/21248035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02000-10
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