Plasmacytoid Dendritic Cells Promote Host Defense Against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway

Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in infants. In human infants, plasmacytoid dendritic cells (pDC) are recruited to the nasal compartment during infection and initiate host defense through the secretion of type I IFN, IL-12 and IL-6. Ho...

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Main Authors: Davidson, Sophia, Kaiko, Gerard, Loh, Zhixuan, Lalwani, Amit, Zhang, Vivian, Spann, Kirsten, Foo, Shen Yun, Hansbro, Nicole, Uematsu, Satoshi, Akira, Shizuo, Matthaei, Klaus I., Rosenberg, Helene F., Foster, Paul S., Phipps, Simon
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404606/
https://ncbi.nlm.nih.gov/pubmed/21482736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002635
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