Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3

After fixation in the human genome, human endogenous retroviruses (HERVs) are bona fide cellular genes despite their exogenous origin. To be able to spread within the germ line and the early embryo, the ancient retroviral promoters must have adapted to the requirements for expression in these cell t...

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Hlavní autoři: Fuchs, Nina V., Kraft, Martin, Tondera, Christiane, Hanschmann, Kay-Martin, Löwer, Johannes, Löwer, Roswitha
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067833/
https://ncbi.nlm.nih.gov/pubmed/21248046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02539-10
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