Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells

BACKGROUND: Malignant human embryonal carcinoma cells (ECCs) rely on similar transcriptional networks as non-malignant embryonic stem cells (ESCs) to control selfrenewal, maintain pluripotency, and inhibit differentiation. Because re-activation of silenced HERV-K(HML-2) loci is a hallmark of ECCs, w...

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Autores principales: Fuchs, Nina V, Loewer, Sabine, Daley, George Q, Izsvák, Zsuzsanna, Löwer, Johannes, Löwer, Roswitha
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819666/
https://ncbi.nlm.nih.gov/pubmed/24156636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-115
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