Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3

After fixation in the human genome, human endogenous retroviruses (HERVs) are bona fide cellular genes despite their exogenous origin. To be able to spread within the germ line and the early embryo, the ancient retroviral promoters must have adapted to the requirements for expression in these cell t...

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Autori principali: Fuchs, Nina V., Kraft, Martin, Tondera, Christiane, Hanschmann, Kay-Martin, Löwer, Johannes, Löwer, Roswitha
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067833/
https://ncbi.nlm.nih.gov/pubmed/21248046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02539-10
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