Human Ago2 Is Required for Efficient MicroRNA 122 Regulation of Hepatitis C Virus RNA Accumulation and Translation

MicroRNA 122 (miR-122) increases the accumulation and translation of hepatitis C virus (HCV) RNA in infected cells through direct interactions with homologous sequences in the 5′ untranslated region (UTR) of the HCV genome. Argonaute 2 (Ago2) is a component of the RNA-induced silencing complex (RISC...

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Bibliographic Details
Main Authors: Wilson, Joyce A., Zhang, Chao, Huys, Adam, Richardson, Christopher D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2011
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067765/
https://ncbi.nlm.nih.gov/pubmed/21177824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02046-10
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