The Presence of Leukocytes in Ex Vivo Assays Significantly Increases the 50-Percent Inhibitory Concentrations of Artesunate and Chloroquine against Plasmodium vivax and Plasmodium falciparum

Plasmodium species ex vivo sensitivity assay protocols differ in the requirement for leukocyte removal before culturing. This study shows that the presence of leukocytes significantly increases the 50% inhibitory concentration (IC(50)) of P. vivax and P. falciparum to artesunate and chloroquine rela...

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Autori principali: Kaewpongsri, S., Sriprawat, K., Suwanarusk, R., Kyle, D. E., Lek-Uthai, U., Leimanis, M., Lwin, K. M., Phyo, A. P., Zwang, J., Russell, B., Nosten, F., Renia, L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
Soggetti:
Analytical Procedures
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067107/
https://ncbi.nlm.nih.gov/pubmed/21189344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01103-10
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