Methotrexate Is Highly Potent Against Pyrimethamine-Resistant Plasmodium vivax

Resistance of vivax malaria to treatment with antifolates, such as pyrimethamine (Pyr), is spreading as mutations in the dihydrofolatereductase (dhfr) genes are selected and disseminated. We tested the antitumor drug methotrexate (MTX), a potent competitive inhibitor of dhfr, against 11 Plasmodium v...

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Bibliografiske detaljer
Main Authors: Imwong, Mallika, Russell, Bruce, Suwanarusk, Rossarin, Nzila, Alexis, Leimanis, Mara L., Sriprawat, Kanlaya, Kaewpongsri, Supaporn, Phyo, Aung Pyae, Snounou, Georges, Nosten, Francois, Renia, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071051/
https://ncbi.nlm.nih.gov/pubmed/21288820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq024
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