Methotrexate Is Highly Potent Against Pyrimethamine-Resistant Plasmodium vivax

Resistance of vivax malaria to treatment with antifolates, such as pyrimethamine (Pyr), is spreading as mutations in the dihydrofolatereductase (dhfr) genes are selected and disseminated. We tested the antitumor drug methotrexate (MTX), a potent competitive inhibitor of dhfr, against 11 Plasmodium v...

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Detalhes bibliográficos
Main Authors: Imwong, Mallika, Russell, Bruce, Suwanarusk, Rossarin, Nzila, Alexis, Leimanis, Mara L., Sriprawat, Kanlaya, Kaewpongsri, Supaporn, Phyo, Aung Pyae, Snounou, Georges, Nosten, Francois, Renia, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071051/
https://ncbi.nlm.nih.gov/pubmed/21288820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq024
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