Hot Spots of Integrase Genotypic Changes Leading to HIV-2 Resistance to Raltegravir

We studied seven heavily pretreated HIV-2-infected patients exhibiting a virological failure while receiving a salvage raltegravir-containing regimen. At the time of virological failure, different resistance genetic pathways were observed: T97A-Y143C, Q148K, Q148R, G140S-Q148R, E92Q-Y143R-N155H, and...

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Detalhes bibliográficos
Main Authors: Charpentier, Charlotte, Roquebert, Bénédicte, Delelis, Olivier, Larrouy, Lucile, Matheron, Sophie, Tubiana, Roland, Karmochkine, Marina, Duval, Xavier, Chêne, Geneviève, Storto, Alexandre, Collin, Gilles, Bénard, Antoine, Damond, Florence, Mouscadet, Jean-François, Brun-Vézinet, Françoise, Descamps, Diane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067093/
https://ncbi.nlm.nih.gov/pubmed/21189351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00942-10
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