p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain.
We have previously reported that wild-type p53 can bind single-stranded (ss) DNA ends and catalyze renaturation of ss complementary DNA molecules. Here we demonstrate that p53 can also bind to internal segments of ss DNA molecules via a binding site (internal DNA site) distinct from the binding site...
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| Izdano u: | Nucleic Acids Res |
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| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
1995
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| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306684/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7885831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.3.362 |
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