p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain.

We have previously reported that wild-type p53 can bind single-stranded (ss) DNA ends and catalyze renaturation of ss complementary DNA molecules. Here we demonstrate that p53 can also bind to internal segments of ss DNA molecules via a binding site (internal DNA site) distinct from the binding site...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Bakalkin, G, Selivanova, G, Yakovleva, T, Kiseleva, E, Kashuba, E, Magnusson, K P, Szekely, L, Klein, G, Terenius, L, Wiman, K G
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 1995
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306684/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7885831/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.3.362
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