Proteolytic cleavage of initiation factor eIF-4 gamma in the reticulocyte lysate inhibits translation of capped mRNAs but enhances that of uncapped mRNAs.

Infection of cells with the foot-and-mouth-disease virus, a member of the picornavirus family, results in the shut-off of host protein synthesis. A major contributory mechanism is the proteolytic destruction of the gamma subunit of the complex eIF-4, which functions in translation to promote the bin...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Ohlmann, T, Rau, M, Morley, S J, Pain, V M
Format: Artigo
Language:Inglês
Published: Oxford University Press 1995
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306680/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7885827/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.3.334
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