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Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

eIF4A is a DEAD-box RNA-dependent ATPase thought to unwind RNA secondary structure in the 5'-untranslated regions (UTRs) of mRNAs to promote their recruitment to the eukaryotic translation pre-initiation complex (PIC). We show that eIF4A's ATPase activity is markedly stimulated in the presence of th...

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Auteurs principaux: Paul Yourik, Colin Echeverría Aitken, Fujun Zhou, Neha Gupta, Alan G Hinnebusch, Jon R Lorsch
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications Ltd 2017-11-01
Collection:eLife
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Accès en ligne:https://elifesciences.org/articles/31476
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