Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

PURPOSE. Choroideremia (CHM) is a progressive X-linked degeneration of three ocular layers (photoreceptors, retinal pigment epithelium, and choroid), with a complex and still largely unclear pathogenesis. To investigate the pathophysiology of CHM, the authors engineered mice with a cell type–specifi...

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Hlavní autoři: Tolmachova, Tanya, Wavre-Shapton, Silene T., Barnard, Alun R., MacLaren, Robert E., Futter, Clare E., Seabra, Miguel C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Association for Research in Vision and Ophthalmology, Inc. 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066613/
https://ncbi.nlm.nih.gov/pubmed/20445111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-4892
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