Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia

Choroideremia (CHM) is an X-linked degeneration of the retinal pigment epithelium (RPE), photoreceptors, and choroid, caused by loss of function of the CHM/REP1 gene. REP1 is involved in lipid modification (prenylation) of Rab GTPases, key regulators of intracellular vesicular transport and organell...

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Autors principals: Tolmachova, Tanya, Anders, Ross, Abrink, Magnus, Bugeon, Laurence, Dallman, Margaret J., Futter, Clare E., Ramalho, José S., Tonagel, Felix, Tanimoto, Naoyuki, Seeliger, Mathias W., Huxley, Clare, Seabra, Miguel C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326146/
https://ncbi.nlm.nih.gov/pubmed/16410831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26617
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