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Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia

X-linked choroideremia (CHM) is a disease characterized by gradual retinal degeneration caused by loss of the Rab Escort Protein, REP1. Despite partial compensation by REP2 the disease is characterized by prenylation defects in multiple members of the Rab protein family that are master regulators of...

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Foilsithe in:PLoS One
Main Authors: Meschede, Ingrid P., Burgoyne, Thomas, Tolmachova, Tanya, Seabra, Miguel C., Futter, Clare E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2020
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7671558/
https://ncbi.nlm.nih.gov/pubmed/33201897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242284
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