The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

Oncogenic Pim-1 kinase is upregulated in multiple solid cancers, including human pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with few useful treatment options. Pim-1 is also transcriptionally induced upon oncogenic K-Ras-mediated transformation of the human pancreatic ductal epi...

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Detalhes bibliográficos
Main Authors: Xu, Dapeng, Allsop, Stephen A., Witherspoon, Sam M., Snider, Jared L., Yeh, Jen Jen, Fiordalisi, James J., White, Catherine D., Williams, Daniel, Cox, Adrienne D., Baines, Antonio T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066419/
https://ncbi.nlm.nih.gov/pubmed/21262926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr007
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