Phosphoproteomics Identifies Oncogenic Ras Signaling Targets and Their Involvement in Lung Adenocarcinomas

BACKGROUND: Ras is frequently mutated in a variety of human cancers, including lung cancer, leading to constitutive activation of MAPK signaling. Despite decades of research focused on the Ras oncogene, Ras-targeted phosphorylation events and signaling pathways have not been described on a proteome-...

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Autors principals: Sudhir, Putty-Reddy, Hsu, Chia-Lang, Wang, Mei-Jung, Wang, Yi-Ting, Chen, Yu-Ju, Sung, Ting-Yi, Hsu, Wen-Lian, Yang, Ueng-Cheng, Chen, Jeou-Yuan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102680/
https://ncbi.nlm.nih.gov/pubmed/21637843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020199
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