Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis

Dietary zinc (Zn) deficiency is implicated in the pathogenesis of human oral–esophageal cancers. In rats, Zn deficiency causes increased cell proliferation and cyclooxygenase-2 (COX-2) overexpression and enhances oral carcinogenesis by 4-nitroquinoline 1-oxide (NQO). Zn replenishment reverses all th...

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Bibliographic Details
Main Authors: Fong, Louise Y.Y., Jiang, Yubao, Rawahneh, Maysoon L., Smalley, Karl J., Croce, Carlo M., Farber, John L., Huebner, Kay
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Cancer Prevention
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066417/
https://ncbi.nlm.nih.gov/pubmed/21245412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr004
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