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Telomere dysfunction alters the chemotherapeutic profile of transformed cells

Telomerase inhibition has been touted as a novel cancer-selective therapeutic goal based on the observation of high telomerase levels in most cancers and the importance of telomere maintenance in long-term cellular growth and survival. Here, the impact of telomere dysfunction on chemotherapeutic res...

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Autori principali: Lee, Kee-Ho, Rudolph, K. Lenhard, Ju, Yeun-Jin, Greenberg, Roger A., Cannizzaro, Linda, Chin, Lynda, Weiler, Sarah R., DePinho, Ronald A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC30662/
https://ncbi.nlm.nih.gov/pubmed/11248087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051629198
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