Augmented Expression and Activity of Extracellular Matrix-Degrading Enzymes in Regions of Low Endothelial Shear Stress Colocalize With Coronary Atheromata With Thin Fibrous Caps in Pigs

BACKGROUND: The molecular mechanisms that determine the localized formation of thin-capped atheromata in the coronary arteries remain unknown. This study tested the hypothesis that low endothelial shear stress augments the expression of matrix-degrading proteases and thereby promotes the formation o...

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Detalhes bibliográficos
Main Authors: Chatzizisis, Yiannis S., Baker, Aaron B., Sukhova, Galina K., Koskinas, Konstantinos C., Papafaklis, Michail I., Beigel, Roy, Jonas, Michael, Coskun, Ahmet U., Stone, Benjamin V., Maynard, Charles, Shi, Guo-Ping, Libby, Peter, Feldman, Charles L., Edelman, Elazer R., Stone, Peter H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066078/
https://ncbi.nlm.nih.gov/pubmed/21282495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.970038
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