Thin-Capped Atheromata with Reduced Collagen Content in Pigs Develop in Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress

OBJECTIVES: The mechanisms promoting the focal formation of rupture-prone coronary plaques in vivo remain incompletely understood. This study tested the hypothesis that coronary regions exposed to low endothelial shear stress (ESS) favor subsequent development of collagen-poor, thin-capped plaques....

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Detalhes bibliográficos
Main Authors: Koskinas, Konstantinos C., Sukhova, Galina K., Baker, Aaron B., Papafaklis, Michail I., Chatzizisis, Yiannis S., Coskun, Ahmet U., Quillard, Thibaut, Jonas, Michael, Maynard, Charles, Antoniadis, Antonios P., Shi, Guo-Ping, Libby, Peter, Edelman, Elazer R., Feldman, Charles L., Stone, Peter H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954496/
https://ncbi.nlm.nih.gov/pubmed/23640495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300827
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