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Therapeutic Benefit of Pentostatin in Severe IL-10(−/−) Colitis
BACKGROUND: Pentostatin, an adenosine deaminase (ADA) inhibitor, is a purine antimetabolite used for the treatment of leukemias. ADA inhibition blunts expansion of proliferating lymphocytes and increases adenosine release, a potent anti-inflammatory molecule. Human inflammatory bowel disease (IBD) i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3065943/ https://ncbi.nlm.nih.gov/pubmed/18340641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.20410 |
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