KINETIC STUDIES OF DRUG-PROTEIN INTERACTIONS BY USING PEAK PROFILING AND HIGH-PERFORMANCE AFFINITY CHROMATOGRAPHY: EXAMINATION OF MULTI-SITE INTERACTIONS OF DRUGS WITH HUMAN SERUM ALBUMIN COLUMNS

Carbamazepine and imipramine are drugs that have significant binding to human serum albumin (HSA), the most abundant serum protein in blood and a common transport protein for many drugs in the body. Information on the kinetics of these drug interactions with HSA would be valuable in understanding th...

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Detalhes bibliográficos
Main Authors: Tong, Zenghan, Schiel, John E., Papastavros, Efthimia, Ohnmacht, Corey M., Smith, Quentin R., Hage, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065503/
https://ncbi.nlm.nih.gov/pubmed/21067755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2010.10.070
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