KINETIC STUDIES OF DRUG-PROTEIN INTERACTIONS BY USING PEAK PROFILING AND HIGH-PERFORMANCE AFFINITY CHROMATOGRAPHY: EXAMINATION OF MULTI-SITE INTERACTIONS OF DRUGS WITH HUMAN SERUM ALBUMIN COLUMNS

Carbamazepine and imipramine are drugs that have significant binding to human serum albumin (HSA), the most abundant serum protein in blood and a common transport protein for many drugs in the body. Information on the kinetics of these drug interactions with HSA would be valuable in understanding th...

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Bibliographic Details
Main Authors: Tong, Zenghan, Schiel, John E., Papastavros, Efthimia, Ohnmacht, Corey M., Smith, Quentin R., Hage, David S.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065503/
https://ncbi.nlm.nih.gov/pubmed/21067755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2010.10.070
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