Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in...

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Detalhes bibliográficos
Main Authors: Stephens, Philip J., Greenman, Chris D., Fu, Beiyuan, Yang, Fengtang, Bignell, Graham R., Mudie, Laura J., Pleasance, Erin D., Lau, King Wai, Beare, David, Stebbings, Lucy A., McLaren, Stuart, Lin, Meng-Lay, McBride, David J., Varela, Ignacio, Nik-Zainal, Serena, Leroy, Catherine, Jia, Mingming, Menzies, Andrew, Butler, Adam P., Teague, Jon W., Quail, Michael A., Burton, John, Swerdlow, Harold, Carter, Nigel P., Morsberger, Laura A., Iacobuzio-Donahue, Christine, Follows, George A., Green, Anthony R., Flanagan, Adrienne M., Stratton, Michael R., Futreal, P. Andrew, Campbell, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065307/
https://ncbi.nlm.nih.gov/pubmed/21215367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.055
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