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Branched RNA: A New Architecture for RNA Interference

Branched RNAs with two and four strands were synthesized. These structures were used to obtain branched siRNA. The branched siRNA duplexes had similar inhibitory capacity as those of unmodified siRNA duplexes, as deduced from gene silencing experiments of the TNF-α protein. Branched RNAs are conside...

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Bibliografiske detaljer
Main Authors: Aviñó, Anna, Ocampo, Sandra M., Perales, José Carlos, Eritja, Ramon
Format: Artigo
Sprog:Inglês
Udgivet: SAGE-Hindawi Access to Research 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065013/
https://ncbi.nlm.nih.gov/pubmed/21461398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/586935
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