Functionally Enhanced siRNA Targeting TNFα Attenuates DSS-induced Colitis and TLR-mediated Immunostimulation in Mice

Tumor necrosis factor (TNFα) is a proinflammatory cytokine involved in the pathogenesis of inflammatory bowel disease (IBD). Although TNFα has been extensively targeted using systemic drugs, the use of antisense and small interfering RNA (siRNA) to drive down its expression at the site of inflammati...

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Detalhes bibliográficos
Main Authors: Ocampo, Sandra M, Romero, Carolina, Aviñó, Anna, Burgueño, Joan, Gassull, Miguel A, Bermúdez, Jordi, Eritja, Ramon, Fernandez, Ester, Perales, Jose C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277229/
https://ncbi.nlm.nih.gov/pubmed/22044934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.236
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