Functionally Enhanced siRNA Targeting TNFα Attenuates DSS-induced Colitis and TLR-mediated Immunostimulation in Mice

Tumor necrosis factor (TNFα) is a proinflammatory cytokine involved in the pathogenesis of inflammatory bowel disease (IBD). Although TNFα has been extensively targeted using systemic drugs, the use of antisense and small interfering RNA (siRNA) to drive down its expression at the site of inflammati...

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Bibliografiske detaljer
Main Authors: Ocampo, Sandra M, Romero, Carolina, Aviñó, Anna, Burgueño, Joan, Gassull, Miguel A, Bermúdez, Jordi, Eritja, Ramon, Fernandez, Ester, Perales, Jose C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277229/
https://ncbi.nlm.nih.gov/pubmed/22044934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.236
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