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Evaluating sequence-derived mtDNA length heteroplasmy by amplicon size analysis

Length heteroplasmy (LH) in mitochondrial (mt)DNA is usually observed in homopolymeric tracts and manifest as mixture of various length variants. The generally used difference-coded annotation to report mtDNA haplotypes does not express the degree of LH variation present in a sample, even more so, i...

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Autors principals: Berger, C., Hatzer-Grubwieser, P., Hohoff, C., Parson, W.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064993/
https://ncbi.nlm.nih.gov/pubmed/21067985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fsigen.2010.10.002
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