Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells

BACKGROUND: While platinum-based chemotherapeutic agents are widely used to treat various solid tumors, the acquired platinum resistance is a major impediment in their successful treatment. Since enhanced DNA repair capacity is a major factor in conferring cisplatin resistance, targeting of DNA repa...

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Bibliografiske detaljer
Main Authors: Wang, Qi-En, Milum, Keisha, Han, Chunhua, Huang, Yi-Wen, Wani, Gulzar, Thomale, Jürgen, Wani, Altaf A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064653/
https://ncbi.nlm.nih.gov/pubmed/21385444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-24
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