Quantification of Cholesterol-Metabolizing P450s CYP27A1 and CYP46A1 in Neural Tissues Reveals a Lack of Enzyme-Product Correlations in Human Retina but not Human Brain

The cytochrome P450 enzymes (CYP or P450) 46A1 and 27A1 play important roles in cholesterol elimination from the brain and retina, respectively, yet they have not been quantified in human organs because of their low abundance and association with membrane. Based on our previous development of a mult...

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Main Authors: Liao, Wei-Li, Heo, Gun-Young, Dodder, Nathan G., Reem, Rachel E., Mast, Natalia, Huang, Suber, DiPatre, Pier Luigi, Turko, Illarion V., Pikuleva, Irina A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064498/
https://ncbi.nlm.nih.gov/pubmed/21049985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr1008898
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