Steroid and Protein Ligand Binding to Cytochrome P450 46A1 as Assessed by Hydrogen – Deuterium Exchange and Mass Spectrometry

Cytochrome P450 46A1 (CYP46A1) is a key enzyme responsible for cholesterol elimination from the brain. This P450 can interact with different steroid substrates and protein redox partners. We utilized hydrogen-deuterium (H-D) exchange mass spectrometry for investigating CYP46A1-ligand interactions. F...

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Bibliographic Details
Main Authors: Liao, Wei-Li, Dodder, Nathan G., Mast, Natalia, Pikuleva, Irina A., Turko, Illarion V.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693120/
https://ncbi.nlm.nih.gov/pubmed/19317426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900168m
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