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Steroid and Protein Ligand Binding to Cytochrome P450 46A1 as Assessed by Hydrogen – Deuterium Exchange and Mass Spectrometry
Cytochrome P450 46A1 (CYP46A1) is a key enzyme responsible for cholesterol elimination from the brain. This P450 can interact with different steroid substrates and protein redox partners. We utilized hydrogen-deuterium (H-D) exchange mass spectrometry for investigating CYP46A1-ligand interactions. F...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693120/ https://ncbi.nlm.nih.gov/pubmed/19317426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900168m |
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