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Characterization of conformational and dynamic properties of natively unfolded human and mouse α-synuclein ensembles by NMR: implication for aggregation
Conversion of human α-synuclein (aS) from the free soluble state to the insoluble fibrillar state has been implicated in the etiology of Parkinson’s disease. Human aS is highly homologous in amino acid sequence to mouse aS which contains seven substitutions including the A53T substitution that is th...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064448/ https://ncbi.nlm.nih.gov/pubmed/18423664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.017 |
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