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Inhibition and Genetic Ablation of the B7/CD28 T cell Costimulation Axis Prevents Experimental Hypertension

BACKGROUND: The pathogenesis of hypertension remains poorly understood and treatment is often unsuccessful. Recent evidence suggests that the adaptive immune response plays an important role in this disease. Various hypertensive stimuli cause T cell activation and infiltration into target organs suc...

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Hlavní autoři: Vinh, Antony, Chen, Wei, Blinder, Yelena, Weiss, Daiana, Robert Taylor, W., Goronzy, Jorg, Weyand, Cornelia, Harrison, David G., Guzik, Tomasz J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064430/
https://ncbi.nlm.nih.gov/pubmed/21126972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.930446
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