Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

A specific small-molecule inhibitor of p97 would provide an important tool to investigate diverse functions of this essential ATPase associated with diverse cellular activities (AAA) ATPase and to evaluate its potential to be a therapeutic target in human disease. We carried out a high-throughput sc...

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Detalles Bibliográficos
Autores principales: Chou, Tsui-Fen, Brown, Steve J., Minond, Dmitriy, Nordin, Brian E., Li, Kelin, Jones, Amanda C., Chase, Peter, Porubsky, Patrick R., Stoltz, Brian M., Schoenen, Frank J., Patricelli, Matthew P., Hodder, Peter, Rosen, Hugh, Deshaies, Raymond J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064330/
https://ncbi.nlm.nih.gov/pubmed/21383145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015312108
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