Evidence of a Role for Activation of Wnt/β-Catenin Signaling in the Resistance of Plasma Cells to Lenalidomide

Lenalidomide plays an important role in our chemotherapeutic armamentarium against multiple myeloma, in part by exerting direct anti-proliferative and pro-apoptotic effects. Unfortunately, long-term exposure leads to the development of drug resistance through unknown mechanisms, and we therefore sou...

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Detalhes bibliográficos
Main Authors: Bjorklund, Chad C., Ma, Wencai, Wang, Zhi-Qiang, Davis, R. Eric, Kuhn, Deborah J., Kornblau, Steven M., Wang, Michael, Shah, Jatin J., Orlowski, Robert Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064156/
https://ncbi.nlm.nih.gov/pubmed/21189262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.180208
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