The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

OBJECTIVE: Ghrelin is a stomach-derived peptide that increases food intake through the activation of hypothalamic AMP-activated protein kinase (AMPK). However, the molecular mechanisms initiated by the activation of the ghrelin receptor, which in turn lead to AMPK activation, remain unclear. Sirtuin...

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Main Authors: Velásquez, Douglas A., Martínez, Gloria, Romero, Amparo, Vázquez, María J., Boit, Katia D., Dopeso-Reyes, Iria G., López, Miguel, Vidal, Anxo, Nogueiras, Ruben, Diéguez, Carlos
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2011
Teme:
Obesity Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064091/
https://ncbi.nlm.nih.gov/pubmed/21386086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0802
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