Inhibition of Kv4.3 by genistein via a tyrosine phosphorylation-independent mechanism

The effects of genistein, a protein tyrosine kinase (PTK) inhibitor, on voltage-dependent K(+) (Kv) 4.3 channel were examined using the whole cell patch-clamp techniques. Genistein inhibited Kv4.3 in a reversible, concentration-dependent manner with an IC(50) of 124.78 μM. Other PTK inhibitors (tyrp...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, Hee Jae, Ahn, Hye Sook, Choi, Bok Hee, Hahn, Sang June
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2011
Konular:
Membrane Transporters, Ion Channels and Pumps
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063965/
https://ncbi.nlm.nih.gov/pubmed/21148405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00031.2010
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