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Inhibition of Kv4.3 by genistein via a tyrosine phosphorylation-independent mechanism
The effects of genistein, a protein tyrosine kinase (PTK) inhibitor, on voltage-dependent K(+) (Kv) 4.3 channel were examined using the whole cell patch-clamp techniques. Genistein inhibited Kv4.3 in a reversible, concentration-dependent manner with an IC(50) of 124.78 μM. Other PTK inhibitors (tyrp...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063965/ https://ncbi.nlm.nih.gov/pubmed/21148405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00031.2010 |
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