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Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins.

Oligo-heptathymidylates covalently linked to porphyrins bind to complementary sequences and can induce local damages on the target molecule. In dark reactions, iron porphyrin derivatives exhibited various chemical reactivities resulting in base oxidation, crosslinking and chain scission reactions. R...

詳細記述

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書誌詳細
主要な著者: Trung Le Doan, Perrouault, L, Chassignol, M, Nguyen, T T, Hélène, C
フォーマット: Artigo
言語:Inglês
出版事項: 1987
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC306396/
https://ncbi.nlm.nih.gov/pubmed/3684568
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