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Novobiocin inhibits initiation of RNA polymerase II-directed transcription of the mouse metallothionein-I gene independent of its effect on DNA topoisomerase II.

The requirement for ATP hydrolysis in the initiation of RNA polymerase II (Pol II)-directed transcription and the relationship between ATP and novobiocin action led us to investigate whether novobiocin could inhibit transcription of the mouse metallothionein-I (MT-I) gene. Novobiocin inhibited the M...

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Bibliografiske detaljer
Main Authors: Webb, M L, Maguire, K A, Jacob, S T
Format: Artigo
Sprog:Inglês
Udgivet: 1987
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC306377/
https://ncbi.nlm.nih.gov/pubmed/2823231
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