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Inhibition of Recombinant L-Type Voltage-Gated Calcium Channels by Positive Allosteric Modulators of GABA(A) Receptors

Benzodiazepines (BDZs) depress neuronal excitability via positive allosteric modulation of inhibitory GABA(A) receptors (GABA(A)R). BDZs and other positive GABA(A)R modulators, including barbiturates, ethanol, and neurosteroids, can also inhibit L-type voltage-gated calcium channels (L-VGCCs), which...

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Detalhes bibliográficos
Main Authors: Earl, Damien E., Tietz, Elizabeth I.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063747/
https://ncbi.nlm.nih.gov/pubmed/21262851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.178244
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