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Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation
1. We have mutated a conserved leucine in the putative membrane-spanning domain to serine in human GABA(A) β2 and investigated the actions of a number of GABA(A) agonists, antagonists and modulators on human α1β2ΔL259Sγ2s compared to wild type α1β2γ2s GABA(A) receptors, expressed in Xenopus oocytes....
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1999
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1760662/ https://ncbi.nlm.nih.gov/pubmed/10455284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702687 |
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