Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation

1. We have mutated a conserved leucine in the putative membrane-spanning domain to serine in human GABA(A) β2 and investigated the actions of a number of GABA(A) agonists, antagonists and modulators on human α1β2ΔL259Sγ2s compared to wild type α1β2γ2s GABA(A) receptors, expressed in Xenopus oocytes....

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Main Authors: Thompson, Sally-Anne, Smith, Maria Z, Wingrove, Peter B, Whiting, Paul J, Wafford, Keith A
格式: Artigo
語言:Inglês
出版: 1999
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Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1760662/
https://ncbi.nlm.nih.gov/pubmed/10455284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702687
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